How do chemotherapeutic agents damage the ovary?

How do chemotherapeutic agents damage the ovary?

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an increased risk of premature ovarian failure (POF) but the exact mechanism through which this occurs is uncertain. In this review we examine the current evidence for the direct action of chemotherapeutic agents on the ovary and discuss possible molecular pathways through which follicle loss may occur. METHODS A syst...

Bone Marrow Osteoblast Damage by Chemotherapeutic Agents

Hematopoietic reconstitution, following bone marrow or stem cell transplantation, requires a microenvironment niche capable of supporting both immature progenitors and stem cells with the capacity to differentiate and expand. Osteoblasts comprise one important component of this niche. We determined that treatment of human primary osteoblasts (HOB) with melphalan or VP-16 resulted in increased p...

How do Robotic Agents’ Appearances

An experimental investigation of how the appearance of robotic agents affects interpretations people make of the agents’ attitudes is described. We conducted a psychological experiment where participants were presented artificial sounds that can make people estimate specific agents’ primitive attitudes from three kinds of agents, e.g., a Mindstorms robot, AIBO robot, and normal laptop PC. They ...

Evaluation of Chemotherapeutic Agents

This fourth, thoroughly revised, edition of Calmette's well-known manual aims to bring together the maximum of information which will be of value to the bacteriologist in his daily work. It is based largely on the techniques utilized at the Pasteur Institute in Paris. The topics included differ from those found in similar manuals in this country which are usually texts of laboratory diagnosis a...

Enzymes as Chemotherapeutic Agents